Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC Chlorprothixene (hydrochloride) | 6469-93-8 | 99.9% | 200 MG
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Chlorprothixene is a dopamine and histamine receptor antagonist known for its antipsychotic activity. It exhibits high affinity for various human dopamine and histamine receptors.
- Antagonizes human D1, D2, D3, D5, and H1 receptors with low nanomolar Ki values.
- Inhibits 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 in HEK293 cells.
- Antagonizes H1 receptor activity in human HeLa cells.
- Binds to 5-HT7, 5-HT6, and 5-HT2 receptors with high pKi values.
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Medchemexpress LLC Nitrendipine | 39562-70-4 | 99.7% | 200 MG
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Nitrendipine (BAY-E-5009) is an orally active dihydropyridine calcium channel blocker, an analog of Nifedipine. It has been shown to induce apoptosis and possess antihypertensive effects. This compound can block alcohol and morphine withdrawal symptoms, reduce right ventricular hypertrophy, and mitigate pulmonary vascular changes induced by intermittent hypoxia. Furthermore, Nitrendipine exhibits anticancer effects on neuroblastoma cells.
- Orally active dihydropyridine calcium channel blocker
- Induces apoptosis
- Provides antihypertensive effects
- Blocks alcohol and morphine withdrawal symptoms
- Reduces right ventricular hypertrophy
- Mitigates pulmonary vascular changes induced by intermittent hypoxia
- Exhibits anticancer effects on neuroblastoma
- Inhibits Cav1.2 current
- Prevents behavioral signs of ethanol withdrawal
- Attenuates lipid peroxidation in the lung
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Medchemexpress LLC Letosteine | 53943-88-7 | 99.8% | 279.38 g·mol⁻1 | C10H17NO4S2 | 200 MG
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Letosteine is an orally active mucolytic expectorant used in research on acute and chronic respiratory diseases. It scavenges reactive oxygen species, dissolves bronchial mucus, reduces respiratory inflammation, and helps restore gas exchange and natural lung defenses.
- Scavenges reactive oxygen species to reduce oxidative stress.
- Dissolves bronchial mucus to improve airway clearance.
- Reduces respiratory inflammation in experimental models.
- Suitable for preclinical research on bronchopneumopathies and respiratory disorders.
- Available in multiple research pack sizes for experimental flexibility.
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Apexbio Technology LLC EMD638683 1181770-72-8 200mg
EMD638683 (CAS 1181770-72-8) is a selective inhibitor of serum- and glucocorticoid-inducible kinases (SGKs) including isoforms SGK1 SGK2 and SGK3 SGK1 regulates key cellular processes such as ion transport survival proliferation and responses to steroid hormones EMD638683 shows inhibitory activity against SGK1 SGK2 and SGK3 (IC50 3 M) significantly reducing SGK-dependent phosphorylation of NDRG1 in vitro It demonstrates limited off-target interactions inhibiting only MSK1 and PRK2 at 1 M while sparing numerous other kinases In cell models EMD638683 influences mitochondrial polarization and caspase activity exhibiting antitumor effects in colorectal tumor cells and antihypertensive activity in vivo
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Medchemexpress LLC PT2399 200 mg
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PT2399 200MG
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Medchemexpress LLC TC-O 9311 200 mg
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TC-O 9311 200MG
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Medchemexpress LLC H111-H7 10 mg
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H111-H7 10MG
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Medchemexpress LLC S-SAR131675 200 mg
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S-SAR131675 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000745474 ELVITEGRAVIR 200MG
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Medchemexpress LLC 50-C2-C9-4TAIL 1 mg
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50-C2-C9-4TAIL 1MG
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Medchemexpress LLC 50-C2-C9-4TAIL 5 mg
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50-C2-C9-4TAIL 5MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000758972 4-BIPHENYLTHIO CARBO 100MG
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Aobchem 2-Fluoro-5-(pyrolidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 874289-42-6 | C11H13BFNO3 | 250mg
2-Fluoro-5-(pyrolidine-1-carbonyl)phenylboronic acid | ≥97% | CAS 874289-42-6 | C11H13BFNO3 | 250mg
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Ambeed AMBEED
5000870219 2-O4-C-METHYLENEADENOSINE 1GR
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Apexbio Technology LLC 1STEP UNIV PROBE 4X MIX-200mg
One-step Universal Probe RT-qPCR 4 Mix is a specialized reagent used in molecular biology research primarily for real-time quantitative polymerase chain reactions (RT-qPCR) This mix originates from advancements in genetic and enzymatic technologies facilitating the detection and quantification of RNA targets It works by employing a universal probe-based system that enhances the specificity and efficiency of amplifying target sequences Known for its high sensitivity this mix operates effectively within the nanomolar to low micromolar concentration range It is commonly utilized in applications including gene expression analysis viral load quantification and biomarker discovery in various cell models and occasionally in animal studies This reagent is integral to high-throughput drug screening processes Experimental concentrations typically depend on the specific research design allowing flexibility for different study requirements
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